Thiouracil, etc. in Experimental Polyarthritis

Thiouracil in Thyrotoxicosis

Experimental polyarthritis in rats injected with a tumour exudate.

It has previously been observed that Murphy rat lymphosarcoma (MRLS) exudate collected from a tumour-pouch could cause typical proliferative arthritis in one or several joints (Jasmin and Richer, 1955). Such articular changes developed in a few days and were aggravated by adrenalectomy (Jasmin and Selye, 1955). It is the purpose of this communication to describe these pathological changes with ...

Effect of experimental renal hypertension on experimental thiouracil-cholesterol atherosclerosis in dogs.

Experimental renal hypertension accelerated the onset and accentuated the severity of thiouracilcholesterol atherosclerosis in dogs. Increased blood pressure and other hemodynamic changes appear to be responsible for these effects. Hypertension and sex were without significant effect on serum cholesterol, cholesterol: phospholipid ratio and low density lipoproteins. Sex had no significant effec...

Enzymatic synthesis of thiouracil riboside and thiouracil desoxyriboside.

In a survey of various substrates for pyrimidine nucleoside synthesis, it was noted that inorganic orthophosphate was released when 2-thiouracil and desoxyribose-l-phosphate were incubated together with thymidine phosphorylase (1). This finding, taken as a fairly certain indication of nucleoside synthesis, has now been fully substantiated by isolation and characterization of crystalline thioura...

Biosynthesis of a Thiouracil Pheomelanin in Embryonic Pigment Cells Exposed to Thiouracil*

[Z-W]Thiouracil and [%]thiouracil are incorporated into the melanin of chick retinal pigment epithelium incubated in vitro. This synthesis of a thiouracil pheomelanin (thiolcuntaining melanin) can be used to measure the rate of melanin synthesis in living cells. Thiouracil incorporation is dependent on tyrosinase activity: incorporation is inhibited by phenylthiourea, a tyrosinase inhibitor, an...